OPTIMIZATION OF RATE OF PENETRATION AND MECHANICAL SPECIFIC ENERGY USING RESPONSE SURFACE METHODOLOGY AND MULTI-OBJECTIVE OPTIMIZATION

Optimization of Rate of Penetration and Mechanical Specific Energy Using Response Surface Methodology and Multi-Objective Optimization

Optimizing the drilling process is critical for the exploration of natural resources.However, there are several mechanic parameters that continuously interact with formation properties, hindering the optimization process.Rate of Melatonin penetration (ROP) and mechanical specific energy (MSE) are considered two key performance indicators that allow

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Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with a poor prognosis.The underlying functions and mechanisms of circular RNA and SUMOylation in the development of ICC remain poorly understood.Methods Circular RNA hsa_circ_0001681 (termed Circ-RAPGEF5 hereafter) was identified by circular RNA sequencing from 19

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Umbilical acupuncture combined with warm needle acupuncture for the treatment of residual numbness after lumbar disc herniation surgery: a protocol of a randomized controlled trial

BackgroundPostoperative residual numbness following lumbar disc herniation (LDH) surgery is a relatively common symptom.Existing drugs and physical therapies are not very Electrolyte effective.Acupuncture is effective for the treatment of LDH, but there are limited reports on its use for postoperative numbness.Based on clinical observations and lit

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Household Wastes as Larval Habitats of Dengue Vectors: Comparison between Urban and Rural Areas of Kolkata, India.

Porcelain and plastic materials constitute bulk of household wastes.Owing to resistibility and slow degradability that accounts for higher residence time, these materials qualify as potential hazardous wastes.Retention of water permits these wastes to form a congenial biotope for the breeding of different vector mosquitoes.Thus porcelain and plasti

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